At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Multi-center, Randomized, Double-blind, Phase IV Clinical Trial on the Diuretic Effects of Acetazolamide in Patients With Decompensated Heart Failure and Volume OveRload
In Brief
A Phase 4 clinical trial evaluating Acetazolamide and Placebo for Acute Decompensated Heart Failure and Volume Overload. Completed, enrolled 519 participants across 1 site.
Detailed Summary
This clinical research study is being conducted in multiple hospitals in Belgium and approximately 519 patients with acute decompensated heart failure are expected to participate. Large-scale research shows that 90% of the physicians treat volume overload with high doses of loop diuretics. However, there is not a lot of scientific data available regarding the optimal doses of these diuretic medications. In addition, it is observed that a lot of people, treated with these drugs, are being readmitted to the hospital due to a new episode of heart failure. The hypothesis of this study is that the volume overload could be better treated when patients receive a combination of different types of diuretics. Additionally, the total dose of the administrated diuretics might be lower this way.
Study Details
Timeline
Interventions
In the experimental group, the patient will receive the standard of care loop diuretics and acetazolamide
In the placebo group, the patient will receive the standard of care loop diuretics and the placebo