At a glance
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Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
In Brief
A Phase 3 clinical trial evaluating Vancomycin for Arthropathy of Knee Joint. Completed, enrolled 24 participants across 1 site.
Detailed Summary
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining adequate tissue levels of the antibiotic than the current standard dose which is given intravenously (IV) through a wrist vein. The use of intraosseous regional administration (IORA) of vancomycin requires the use of a tourniquet for the duration of the procedure. Many surgeons prefer to perform the surgery with tourniquet use minimised or without a tourniquet at all. The aim of this study is to evaluate whether IORA vancomycin can achieve effective tissue concentrations with tourniquet use minimised.
Study Details
Timeline
Interventions
Antibiotic