CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 270 enrolled
Drug / intervention
Sodium Zirconium Cyclosilicate 5g +2 moredrug
Likely dose
Sodium Zirconium Cyclosilicate 5gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03528681
NCT03528681Phase 3Completed

A Phase 3 Multicenter, Prospective, Randomized, Double-blind, Placebo-controlled Study to Investigate the Safety and Efficacy of ZS (Sodium Zirconium Cyclosilicate), in Patients With Hyperkalemia-HARMONIZE Asia

AstraZeneca·interventional·Posted May 18, 2018·Updated May 14, 2025

In Brief

A Phase 3 clinical trial evaluating Sodium Zirconium Cyclosilicate 5g, Sodium Zirconium Cyclosilicate 10g, and 1 other intervention for Hyperkalemia. Completed, enrolled 270 participants across 66 sites in 2 countries.

Detailed Summary

To evaluate the efficacy of two different doses (5 and 10 g) of ZS orally administered once daily (qd) vs placebo in maintaining normokalemia in initially hyperkalemic patients having achieved normokalemia following 24 or 48 hours of initial ZS therapy (10g TID).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHyperkalemia
CountriesChina, India
Collaborators--

Timeline

Phase 3CompletedFinished
20192020202120222023202420252026
First PostedMay 18, 2018
Enrollment StartMay 6, 2021
Primary CompletionSep 15, 2022
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 8.1 years ago

Interventions

Sodium Zirconium Cyclosilicate 5gdrug

Suspension administered Sodium Zirconium Cyclosilicate 5g orally once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.

Sodium Zirconium Cyclosilicate 10gdrug

Suspension administered Sodium Zirconium Cyclosilicate 10g orally once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.

Placebodrug

Suspension administered orally placebo once daily for 28 days after the open label initial phase with suspension administered Sodium Zirconium Cyclosilicate 10g orally three times per day for at most 2 days.