CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 95 enrolled
Drug / intervention
AMX0035 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03533257
NCT03533257Phase 2Completed

Phase II Study to Assess the Safety, Tolerability, and Target Engagement of AMX0035, a Fixed Combination of Sodium Phenylbutyrate and Tauroursodeoxycholic Acid for the Treatment of Alzheimer's Disease

Amylyx Pharmaceuticals Inc.·interventional·Posted May 23, 2018·Updated Mar 7, 2025

In Brief

A Phase 2 clinical trial evaluating AMX0035 and Placebo for Alzheimer Disease. Completed, enrolled 95 participants across 11 sites.

Detailed Summary

The study is a 24-week, randomized, double-blind, multi-site, placebo-controlled study in participants with mild cognitive impairment (MCI) or early dementia due to Alzheimer's disease (AD).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedMay 23, 2018
Enrollment StartSep 14, 2018
Primary CompletionOct 22, 2020
Study CompletionNov 6, 2020
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 8.1 years ago

Interventions

AMX0035drug

Combination Therapy of PB and TURSO

Placebodrug

Placebo