At a glance
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Randomized Controlled Experimental Trial Designed to Test the Effects of Probiotics on Mood
In Brief
A clinical study evaluating Bifihappy and Placebo for Depression, Anxiety. Completed, enrolled 39 participants across 1 site.
Detailed Summary
Recent demonstration that probiotics administration has positive effects on depressive feelings in healthy populations suggests its possible role as an adjuvant therapy for depression in clinical populations and as a non-invasive strategy to prevent depressive feelings in healthy individuals. The present study extends current knowledge on the beneficial effects of probiotics on psychological well-being, as measured by changes in mood (e.g., depression, anxiety, cognitive reactivity to sad mood), personality dimensions, and quality of sleep, which have been considered as related to mood. For this double-blind, placebo-controlled study healthy volunteers pseudo-randomly assigned to an experimental or control group assumed a daily dose of probiotic or placebo, respectively, for 6 weeks. Mood, personality dimensions, and sleep quality were assessed four times (before the beginning of the study, at 3 and 6 weeks, and at 3 weeks of washout).
Study Details
Timeline
Interventions
During the six weeks of treatment, the experimental group will take daily doses of 2,5 g with a concentration of 4x109 CFU/sachet of a mixture of lyophilised probiotic strains of the following species: * Lactobacillus fermentum * Lactobacillus rhamnosus * Lactobacillus plantarum * Bifidobacterium longum
During the six weeks of treatment, the experimental group will take daily doses of 2,5 g of maltodextrin