At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Sleep and Circadian Mechanisms Contributing to Nocturnal Non-dipping Blood Pressure
In Brief
An observational study evaluating Forced Desynchrony for Hypertension and Cardiovascular Risk Factor. Completed, enrolled 30 participants across 1 site.
Signals
Detailed Summary
This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on mechanisms, such as targeting sleep, targeting circadian rhythmicity, or targeting behaviors, and raising the possibility that ideal therapy for hypertension (HTN) may differ by race. This research will ultimately help to improve health and survival in black populations with HTN.
Study Details
Timeline
Arms & Interventions
White adults aged 30-60 with a BMI of 18.5\<BMI\<40 kg/m2 who are non-smokers (≥1 year), not on prescription medications (except oral contraceptives), and have had no recent shift work or major travel. Mild, unmanaged hypertension (below 160/100) and renal disease are allowed.
Black adults aged 30-60 with a BMI of 18.5\<BMI\<40 kg/m2 who are non-smokers (≥1 year), not on prescription medications (except oral contraceptives), and have had no recent shift work or major travel. Mild, unmanaged hypertension (below 160/100) and renal disease are allowed.
Interventions
Participants will complete a 7-day circadian study protocol with numerous repeated blood pressure and other cardiovascular measures across the circadian cycle. All sleep opportunities and other activities will be scheduled by the experimenter so that by the end of the study these activities are spread evenly across all phases of the internal body clock.