At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase Ib and Open Label Phase II Study of CFI-402257 in Combination With Weekly Paclitaxel in Patients With Advanced/Metastatic HER2-Negative Breast Cancer
In Brief
A Phase 2 clinical trial evaluating CFI-402257 and Paclitaxel for Breast Cancer. Active but no longer recruiting, targeting 37 participants across 4 sites.
Detailed Summary
The standard or usual treatment for this disease is to undergo chemotherapy to slow the spread of disease and relieve some symptoms of cancer. One of the standard types of chemotherapy is a drug called paclitaxel (Taxol) given in a low dose every week for three out of four weeks. CFI-402257 is a new type of drug for breast cancer. Laboratory tests show that it may help slow the growth of breast cancer. This drug has been shown to shrink tumours in animals. CFI-402257 has been studied in a few people and appears well tolerated with little side effects. CFI-402257 seems promising but it is not clear if it can offer better results when given with paclitaxel compared to paclitaxel alone.
Study Details
Timeline
Interventions
Orally taken on intermittent schedule (days 1, 2, 8, 9, 15 \& 16
80 mg/m2 IV days 1, 8 \& 15 every 28 days