At a glance
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A Randomized, Open-Label Study to Assess the Pain, Toxicity, and Quality of Life Effects of Adding Venlafaxine to the Pain Management Regimen for Patients Treated With Chemoradiation for Head and Neck Cancer
In Brief
A Phase 2 clinical trial evaluating Gabapentin, Methadone, and 5 other interventions for Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 and Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8. Completed, enrolled 62 participants across 1 site.
Detailed Summary
This trial studies how well gabapentin, methadone, and oxycodone with or without venlafaxine hydrochloride work in managing pain in participants with stage II-IV squamous cell head and neck cancer undergoing chemoradiation therapy. Gabapentin may reduce the need for these pain medications if given at the start of radiation therapy. Methadone and oxycodone may help relieve pain caused by cancer. Venlafaxine hydrochloride may prevent or improve pain caused by cancer. It is now yet known whether giving gabapentin, methadone, and oxycodone with venlafaxine hydrochloride will work better in managing pain in participants with squamous cell head and neck cancer undergoing chemoradiation therapy.
Study Details
Timeline
Interventions
Given PO
Given PO
Given PO
Ancillary studies
Ancillary studies
Given PO
Given PO