CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 131 enrolled
Drug / intervention
Stretching and Spinal manipulative therapy +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03576846
NCT03576846N/ACompleted
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The Effect of Spinal Manipulative Therapy on Heart Rate Variability and Pain, and the Predictive Value of Conditioned Pain Modulation

Karolinska Institutet·interventional·Posted Jul 3, 2018·Updated Dec 24, 2025

In Brief

A clinical study evaluating Stretching and Spinal manipulative therapy and Stretching for Neck Pain. Completed, enrolled 131 participants across 2 sites.

Detailed Summary

This randomized, single-blinded study will investigate the effects of Spinal Manipulative Therapy on Heart Rate Variability and Pain Sensitivity in a population of patients with recurrent and persistent neck pain. Alongside, the study will also develop a clinical test for Conditioned Pain Modulation and investigate its predictive properties.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNeck Pain
CountriesSweden
CollaboratorsUniversity of Southern Denmark

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedJul 3, 2018
Enrollment StartJan 4, 2019
Primary CompletionMay 2, 2020
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 8.0 years ago

Interventions

Stretching and Spinal manipulative therapyother

Subjects will be instructed to perform a series of progressively difficult stretching exercises for the neck and upper back muscles. In addition, subjects will be treated with Spinal manipulative therapy

Stretchingother

Subjects will be instructed to perform a series of progressively difficult stretching exercises for the neck and upper back muscles.