CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 96 enrolled / 96 target
Drug / intervention
EPA+DHA +1 moredietary
Likely dose
1.87 gfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03576989
NCT03576989N/ACompletedOn Track (1.1/mo)Completion was 18mo ago
CompareCT.gov

Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults

Ohio State University·interventional·Posted Jul 5, 2018·Updated Jun 17, 2026

In Brief

A clinical study evaluating EPA+DHA and placebo for Chronic Venous Leg Ulcers. Completed, enrolled 96 participants across 1 site.

Detailed Summary

The purpose of this study is to test the efficacy of an oral, nutrient intervention containing the bioactive components of fish oil to promote healing of chronic venous leg ulcers (CVLUs) by reducing the chronic inflammation at wound sites that prevents healing progression. If this systemic, nutrient intervention is found to alter the microenvironment of CVLUs, the science of wound healing and care of patients with CVLUs will be vastly improved.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Venous Leg Ulcers
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedJul 5, 2018
Enrollment StartApr 15, 2019
Primary CompletionDec 18, 2024
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 8.0 years ago

Arms & Interventions

EPA+DHA Groupexperimental

12 weeks of daily oral therapy with EPA+DHA (three opaque softgels to provide a total daily intake of 1.87 g of EPA + 1.0 g of DHA)

Dietary Supplement: EPA+DHA
Placebo Groupplacebo_comparator

12 weeks of daily oral therapy with placebo (three opaque softgels to provide a total daily intake of 2.5 mL of mineral oil)

Other: placebo

Interventions

EPA+DHAdietary

EPA+DHA are the n-3 polyunsaturated fatty acids contained in fish oil

placeboother

placebo contains mineral oil