CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 71 enrolled
Drug / intervention
Caffeine Citrate +1 moredrug
Likely dose
Caffeine Citrate 200 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03577730
NCT03577730Early Ph 1Completed
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Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

University of Michigan·interventional·Posted Jul 5, 2018·Updated Oct 6, 2021

In Brief

A Early Phase 1 clinical trial evaluating Caffeine Citrate and Dextrose Water for Pain, Postoperative. Completed, enrolled 71 participants across 1 site.

Detailed Summary

The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery. Thus, the purpose of this study is to test whether caffeine reduces pain and opioid requirements after surgery. The investigators will also test whether caffeine improves mood and brain function (e.g., learning, memory) after surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPain, Postoperative
CountriesUnited States
Collaborators--

Timeline

Early Ph 1CompletedFinished
20192020202120222023202420252026
First PostedJul 5, 2018
Enrollment StartJul 10, 2018
Primary CompletionNov 21, 2019
Study CompletionJan 17, 2020
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 8.0 years ago

Interventions

Caffeine Citratedrug

Prepared intravenous piggyback solutions of caffeine citrate (200 mg caffeine) will be directly delivered to the operating room prior to the surgery of enrolled participants.

Dextrose Waterdrug

Prepared intravenous piggyback solutions of 5 percent dextrose water will be directly delivered to the operating room prior to the surgery of enrolled participants.