CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 10 enrolled
Drug / intervention
Fibrinolytic Therapy +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03583931
NCT03583931N/ACompleted
CompareCT.gov

Early Intervention for Complicated Parapneumonic Effusion: Randomized Controlled Trial for Fibrinolytic Therapy Versus VATs Decortication

Denver Health and Hospital Authority·interventional·Posted Jul 12, 2018·Updated Jan 27, 2022

In Brief

A clinical study evaluating VATS Decortication and Fibrinolytic Therapy for Parapneumonic Effusion and 2 related conditions. Completed, enrolled 10 participants across 1 site.

Detailed Summary

This study aims to standardize the treatment of pleural space (parapneumonic) infections by comparing the difference in outcomes between 2 methods of treatment: early VATS (Video Assisted Thorascopic Surgery) decortication versus fibrinolytic therapy. During treatment, the patient's coagulopathy status will also be evaluated.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsParapneumonic Effusion, Empyema, Pleural, Coagulopathy
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedJul 12, 2018
Enrollment StartJul 26, 2018
Primary CompletionFeb 2, 2020
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 8.0 years ago

Interventions

VATS Decorticationprocedure

Surgical procedure to unroof all located collections of the pleural space through a chest wall incision

Fibrinolytic Therapydrug

Instillation of DNAse and tPA together through patient's chest tube already in placed to break down complex fluid collection in the pleural space. DNAse and tPA are are administered together only i.e. are not mutually exclusive.