CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 99 enrolled
Drug / intervention
hip arthroplastyprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03585647
NCT03585647N/ACompleted
CompareCT.gov

Effect of Anesthetics Used for Regional vs General vs Integrated Anesthesia on the Modulation of 'Stress-responsive' Genes Involved in the Metabolism and Cellular Detoxification

University of Bologna·observational·Posted Jul 13, 2018·Updated Apr 17, 2019

In Brief

An observational study evaluating hip arthroplasty for Hip Arthroplasty. Completed, enrolled 99 participants across 1 site.

Detailed Summary

The study will analyze differentially regulated genes involved in oxidative stress and toxicology in peripheral blood mononuclear cells (PBMCs) of patients who underwent arthroplasty under three different anesthetic methods. The investigator hypothesized that anesthesia procedures trigger toxicity, thus inducing changes in the messenger ribonucleic acid (mRNA) profile. The results may provide a more profound understanding of the molecular mechanism of anesthesia and in overcoming the adverse effects arising from their use.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsHip Arthroplasty
CountriesItaly
Collaborators--

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedJul 13, 2018
Enrollment StartSep 15, 2014
Primary CompletionJun 20, 2015
Study CompletionNov 30, 2016
TodayJul 2, 2026
Enrollment to primary: 9 monthsPosted 8.0 years ago

Interventions

hip arthroplastyprocedure

Hip replacement is a surgery for people with severe hip damage. The most common cause of damage is osteoarthritis.