CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 193 enrolled
Drug / intervention
Stress Reduction Training A +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03592329
NCT03592329N/ACompleted
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Brain Mechanisms of Vagus Nerve Stimulation and Stress Reduction Training for Migraine

Massachusetts General Hospital·interventional·Posted Jul 19, 2018·Updated Feb 25, 2026

In Brief

A clinical study evaluating Stress Reduction Training A, active tVNS, and 2 other interventions for Migraine. Completed, enrolled 193 participants across 1 site.

Detailed Summary

This study design has two components: 1) a cross-sectional assessment of brain activity and inflammation in migraine patients compared to healthy controls and 2) an assessment of 8 weeks of a combination therapy approach to treating migraine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMigraine
CountriesUnited States
CollaboratorsNational Institutes of Health (NIH), National Center for Complementary and Integrative Health (NCCIH)

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedJul 19, 2018
Enrollment StartAug 20, 2019
Primary CompletionJan 14, 2025
Study CompletionMay 29, 2025
TodayJul 2, 2026
Enrollment to primary: 5.4 yearsPosted 8.0 years ago

Interventions

Stress Reduction Training Abehavioral

twice weekly "booster" sessions and weekly instructor-led sessions for 8 weeks plus home practice sessions

active tVNSdevice

non-painful electrical stimulation of the auricle

Stress Reduction Training Bbehavioral

twice weekly "booster" sessions and weekly instructor-led sessions for 8 weeks plus home practice sessions

sham tVNSdevice

sham stimulation