CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 126 enrolled
Drug / intervention
Spinal Hydromorphone +1 moredrug
Likely dose
Spinal Hydromorphone 75 mcgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03592992
NCT03592992Phase 4Completed
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Spinal Hydromorphone Versus Morphine for Post-Cesarean Delivery Analgesia: A Non-Inferiority Trial

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's·interventional·Posted Jul 19, 2018·Updated Apr 3, 2023

In Brief

A Phase 4 clinical trial evaluating Spinal Hydromorphone and Spinal Morphine for Postoperative Pain. Completed, enrolled 126 participants across 1 site.

Detailed Summary

Morphine is usually used for pain relief after cesarean delivery. However, sometimes it is not available, the patient might be allergic to morphine or intolerant to its side effects. Hydromorphone, another drug from the same class, might be used alternatively, but we need to prove that it is not inferior to morphine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Pain
CountriesCanada
Collaborators--

Timeline

Phase 4CompletedFinished
20192020202120222023202420252026
First PostedJul 19, 2018
Enrollment StartNov 11, 2020
Primary CompletionJul 28, 2022
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 8.0 years ago

Interventions

Spinal Hydromorphonedrug

75 mcg of hydromorphone will be prepared in a non-identifiable syringe by central hospital pharmacy. The resulting solution will then be added to the spinal anesthetic mixture(fentanyl 15 mcg and 0.75% hyperbaric bupivacaine 1.4-1.6 mcg at the discretion of the attending anesthesiologist, adjusted to height and weight)

Spinal Morphinedrug

150 mcg of morphine will be prepared in a non-identifiable syringe by central hospital pharmacy.The resulting solution will be added to the spinal anesthetic mixture (fentanyl 15 mcg and 0.75% hyperbaric bupivacaine 1.4-1.6 mcg at the discretion of the attending anesthesiologist, adjusted to height and weight)