At a glance
ClinicalIndex Comparison Record- ✓Age 18 to 89 with traumatic spinal cord injury
- ✓Any level or severity of SCI (AIS grade A–D)
- ✓Non-ventilator dependent and primarily wheelchair dependent for mobility
- ✓Duration of spinal cord injury less than 1 year
- ✕Current illness or infection
- ✕Frequent or severe autonomic dysreflexia (>3 symptomatic events per week, BP ≥140/90 mmHg, or significant adverse symptoms)
- ✕Hypertension
- ✕Any neurological condition other than SCI (Alzheimer's, dementia, stroke, multiple sclerosis, Parkinson's disease)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
In Brief
A Phase 4 clinical trial evaluating Northera and Placebo for Hypotension, Orthostatic and 2 related conditions. Completed, enrolled 22 participants across 2 sites.
Detailed Summary
The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males and 100/70 in females. The first aim is to determine the proportion of subject with Spinal Cord Injury (SCI) who have a normotensive response to Droxidopa. The second is to determine the proportion of subject with SCI who express a hypertensive response to Droxidopa. A Normal blood pressure ranges from 111-139 in males and 101-139 in females and a hypertensive blood pressure is anything higher than 140 in males and females. The study would take place in James J. Peters VA Medical Center (JJPVAMC) and The Icahn School of Medicine at Mount Sinai (ISMMS) in Manhattan, New York.
Study Details
Timeline
Interventions
Study 1 is a dose optimization, open-label trial of Northera from a dose range of 200mg up to 800mg.
Study 2 is blinded placebo controlled trial using the individualized optimal dose of droxidopa determined by study 1.