At a glance

ClinicalIndex Comparison Record

N/ACompleted· 40 enrolled

Drug / intervention

High Flow Nasal Cannula (HFNC) +1 moredevice

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03615417

NCT03615417N/ACompleted

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Effectiveness of High-Flow Nasal Cannula (HFNC) Preoxygenation in Obese Patients Undergoing General Anesthesia: A Randomised Controlled Trial

Erasme University Hospital·interventional·Posted Aug 3, 2018·Updated Nov 19, 2018

In Brief

A clinical study evaluating High Flow Nasal Cannula (HFNC) and Standard anesthesia FaceMask (FM) for Preoxygenation and 2 related conditions. Completed, enrolled 40 participants across 1 site.

Detailed Summary

This study aims to evaluate the effectiveness of the High Flow Nasal Cannula (HFNC) for the preoxygenation of obese patients undergoing a general anesthesia. The HFNC interface is compared to a standard anesthesia FaceMask (FM) preoxygenation with Continuous Positive Airway Pressure (CPAP), the current gold standard procedure for obese induction. The interest of HFNC preoxygenation is to increase the "safe apnea time" before critical arterial desaturation, useful in the management of difficult airways, especially in subjects with reduced respiratory reserves such as the obese.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsPreoxygenation, Anesthesia, Obesity

CountriesBelgium

Collaborators--

Timeline

N/ACompletedFinished

20192020202120222023202420252026

Enrollment StartApr 2018

First PostedAug 2018

Primary CompletionSep 2018

TodayJul 2026

First PostedAug 3, 2018

Enrollment StartApr 19, 2018

Primary CompletionSep 7, 2018

TodayJul 2, 2026

Enrollment to primary: 5 monthsPosted 7.9 years ago

Interventions

High Flow Nasal Cannula (HFNC)device

Preoxygenation trough High Flow Nasal Cannula (HFNC) at 100% FiO2, 50 liters/min and closed mouth. After Rapid Sequence Induction (RSI), maintenance of apnea with HFNC at 100% FiO2, 70 liters/min and jaw thrust. At time of peripheral oxygen saturations (SpO2) decreases by 2% or after 10 minutes of apnea, the participant is intubated.

Standard anesthesia FaceMask (FM)device

Preoxygenation trough standard anesthesia FaceMask (FM) at 100% FiO2, 12 liters/min, CPAP 7 cmH2O. After Rapid Sequence Induction (RSI), maintenance of apnea without mask. At time of peripheral oxygen saturations (SpO2) decreases by 2% or after 10 minutes of apnea, the participant is intubated.