At a glance
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Phase I Study of WST11 Phototherapy for Upper Tract Urothelial Carcinoma
In Brief
A Phase 1 clinical trial evaluating WST11 mediated vascular targeted phototherapy (VTP) and Endoscopy for Upper Tract Urothelial Carcinoma. Completed, enrolled 30 participants across 1 site.
Detailed Summary
The purpose of this study is to test the safety of a combination of the study drug called WST11 and PDT. Photodynamic therapy (PDT) is a type of ablation therapy (treatment which destroys tumor cells) which has been previously approved for the treatment of patients with other cancers. It works by using a drug that is given through the vein and then is activated in the tumor by light administered during endoscopy, which results in destruction of the cancer cells.
Study Details
Timeline
Interventions
All patients will receive intravenous administration of WST11 at a dose of 4 mg/kg, infused over 10 minutes while patients are under anesthesia during their endoscopy procedure, followed by immediate laser light application.
Endoscopy of the bladder