CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 16 enrolled
Drug / intervention
Experimental: Nitrate-containing +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03617302
NCT03617302Early Ph 1Completed
CompareCT.gov

Effects of Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

Gary L. Pierce, PhD·interventional·Posted Aug 6, 2018·Updated Mar 4, 2026

In Brief

A Early Phase 1 clinical trial evaluating Experimental: Nitrate-containing and Placebo: Nitrate-depleted for Aging and 4 related conditions. Completed, enrolled 16 participants across 1 site.

Detailed Summary

This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults. Participants will be randomized to consume either nitrate-containing or nitrate-depleted beetroot juice.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAging, Arterial Stiffness, Endothelial Dysfunction, Hypertension, Cognitive Decline
CountriesUnited States
CollaboratorsUniversity of Wisconsin, Madison

Timeline

Early Ph 1CompletedFinished
20192020202120222023202420252026
First PostedAug 6, 2018
Enrollment StartNov 1, 2018
Primary CompletionDec 30, 2022
Study CompletionJun 30, 2024
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 7.9 years ago

Interventions

Experimental: Nitrate-containingdrug

Experimental

Placebo: Nitrate-depleteddrug

Placebo