CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 35 enrolled
Drug / intervention
Levosimendandrug
Likely dose
Levosimendan 2.5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03624010
NCT03624010Phase 2Completed

Open-Label Rollover Study of Levosimendan in Patients With Pulmonary Hypertension With Heart Failure and Preserved Left Ventricular Ejection Fraction (PH-HFpEF)

Tenax Therapeutics, Inc.·interventional·Posted Aug 9, 2018·Updated Apr 22, 2026

In Brief

A Phase 2 clinical trial evaluating Levosimendan for Hypertension Pulmonary Secondary Heart Failure and 2 related conditions. Completed, enrolled 35 participants across 9 sites.

Detailed Summary

PH-HFpEF patients will receive open-label doses of levosimendan and be periodically evaluated for safety in extended use.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
CollaboratorsMedpace, Inc.

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedAug 9, 2018
Enrollment StartApr 9, 2019
Primary CompletionApr 25, 2023
TodayJul 2, 2026
Enrollment to primary: 4.0 yearsPosted 7.9 years ago

Interventions

Levosimendandrug

Initial: A sterile 2.5 mg/mL concentrate solution that is diluted in 5% Dextrose or 0.9 Normal Saline to achieve a 50 microgram/min solution for a weekly 24 hour infusion. Transioned to: Daily Levosimendan capsules (1 mg TID)