CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 135 enrolled
Drug / intervention
Neuromuscular Electrical Stimulation (NMES) +3 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03626857
NCT03626857N/ACompleted
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MiACLR: Michigan Initiative for Anterior Cruciate Ligament Rehabilitation

University of Michigan·interventional·Posted Aug 13, 2018·Updated Jan 2, 2026

In Brief

A clinical study evaluating Neuromuscular Electrical Stimulation (NMES), Eccentric Exercise (ECC), and 2 other interventions for Anterior Cruciate Ligament Injury. Completed, enrolled 135 participants across 2 sites.

Detailed Summary

This clinical trial evaluates interventions to maximize muscle function and improve cartilage health following anterior cruciate ligament reconstruction. Improving muscle function may improve patient outcomes, improve joint mechanics, and potentially serve as a prevention approach for post-traumatic knee osteoarthritis. Knee osteoarthritis (OA) is a disabling disease that carries a substantial burden to society and to the individual affected.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAnterior Cruciate Ligament Injury
CountriesUnited States
CollaboratorsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), University of Connecticut, University of Delaware, University of North Carolina, Chapel Hill

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedAug 13, 2018
Enrollment StartFeb 22, 2019
Primary CompletionJan 9, 2025
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 7.9 years ago

Interventions

Neuromuscular Electrical Stimulation (NMES)device

The electrical stimulator will deliver a 2500 Hz alternating current, modulated at 75 bursts/s, with a ramp-up time of 2-seconds, followed by a 50-second rest period. Stimulus intensity set to generate a maximum voluntary isometric contraction (MVIC) of at least 40\& of the contralateral MVIC.

Eccentric Exercise (ECC)other

4 sets of 10 repetitions of an eccentric leg press exercise performed at 70-90% of the 1 repetition maximum

Neuromuscular Electrical Stimulation (NMES) placebodevice

The electrical stimulator will deliver a 2500 Hz alternating current, modulated at 75 bursts/s, with a ramp-up time of 2-seconds, followed by a 50-second rest period. Stimulus intensity set to generate a maximum voluntary isometric contraction (MVIC) of 10-20% of the contralateral MVIC.

Eccentric Exercise (ECC) placeboother

4 sets of 10 repetitions of an eccentric leg press exercise performed at 10-20% of the 1 repetition maximum