CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 29 enrolled
Drug / intervention
Acute Intermittent Hypoxia +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03645031
NCT03645031N/ACompleted
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Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease

University of Florida·interventional·Posted Aug 24, 2018·Updated May 15, 2025

In Brief

A clinical study evaluating Acute Intermittent Hypoxia and Sham Acute Intermittent Hypoxia for Amyotrophic Lateral Sclerosis (ALS) and Neuromuscular Diseases. Completed, enrolled 29 participants across 2 sites.

Detailed Summary

This project seeks to investigate the effects of a single acute intermittent hypoxia (AIH) session on respiratory and non-respiratory motor function and EMG (electromyography) activity on patients with ALS (amyotrophic lateral sclerosis) and healthy controls.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAmyotrophic Lateral Sclerosis (ALS), Neuromuscular Diseases
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedAug 24, 2018
Enrollment StartOct 1, 2018
Primary CompletionJun 2, 2023
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 7.9 years ago

Interventions

Acute Intermittent Hypoxiaother

AIH entails continuous breathing as the level of oxygen in the air is decreased, then returned to normal. Participants will alternate between breathing normal air and breathing hypoxic air (air that has less oxygen). Participants will complete a single 45 minute session of acute intermittent hypoxia (AIH). Breathing, muscle activity and heart activity will be monitored before, during and after the procedure. The intervals will last 1 minute each.

Sham Acute Intermittent Hypoxiaother

Participants will complete the sham acute intermittent hypoxia, consisting of a single 45 minute session of breathing air with normal oxygen levels. All aspects of this procedure will otherwise be the same as for the AIH procedure. Breathing, muscle activity and heart activity will be monitored before, during and after the procedure.