At a glance
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Plasticity in the Spinal Cord to Enhance Motor Retraining After Stroke
In Brief
A clinical study evaluating Paired corticospinal-motoneuronal stimulation (PCMS) and Sham stimulation for Stroke and 2 related conditions. Completed, enrolled 23 participants across 1 site.
Detailed Summary
The objective of this project is to study the effects of an emerging noninvasive neuromodulation strategy in human stroke survivors with movement-related disability. Muscle weakness after stroke results from the abnormal interaction between cells in the brain that send commands to control movement and cells in the spinal cord that cause muscles to produce movement. The neuromodulation strategy central to this project has been shown the strengthen the physical connection between both cells, producing a change in movement potential of muscles weakened by stroke.
Study Details
Timeline
Interventions
Synapses in the spinal cord that transmit voluntary movement commands from the brain to hand muscles will be activated by noninvasive stimulation in a particular sequence and interval that has been shown to strengthen connectivity.
Synapses in the spinal cord that transmit voluntary movement commands from the brain to hand muscles will not be activated by noninvasive stimulation in a particular sequence and interval that has been shown to strengthen connectivity.