CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 25 enrolled
Drug / intervention
Placebo +2 moredrug
Likely dose
Nicotine 4 milligramfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03652740
NCT03652740Phase 1Completed
CompareCT.gov

Effects of Commonly Used Medications on Mood and Choice

Johns Hopkins University·interventional·Posted Aug 29, 2018·Updated Feb 2, 2026

In Brief

A Phase 1 clinical trial evaluating Placebo, Methylphenidate, and 1 other intervention for Healthy. Completed, enrolled 25 participants across 1 site.

Detailed Summary

This non-treatment study will examine how commonly used prescription or over-the-counter medications may influence mood and medication preference.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Phase 1CompletedFinished
20192020202120222023202420252026
First PostedAug 29, 2018
Enrollment StartOct 2, 2018
Primary CompletionFeb 1, 2024
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 7.8 years ago

Interventions

Placebodrug

Capsules will contain a commonly prescribed or over-the-counter medication, or placebo. A placebo is an inactive substance that looks like the study drug, but contains no active drug.

Methylphenidatedrug

Methylphenidate hydrochloride is administered orally at 10, 20, and 40 milligeam doses.

Nicotinedrug

Nicotine is administered orally via capsule at 1, 2, 3 and 4 milligram doses.