At a glance
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Diagnosing Sport-related Concussion Using Urine Metabolomics: A 1H NMR-Based Analysis
In Brief
A clinical study evaluating urine metabolomics for Concussion, Mild and Diagnoses, Syndromes, and Conditions. Completed, enrolled 120 participants across 1 site.
Detailed Summary
Millions of sport related concussions (SRC) occur yearly in the United States, and current diagnosis of concussion is based upon largely subjective clinical evaluations. The objective of this study is to determine whether urinary metabolites are significantly altered post SRC. Urine of 26 athletes will be analyzed pre-injury and after SRC by 1H NMR spectroscopy. Data will be analyzed using multivariate statistics, pairwise t-test, and metabolic pathway analysis. Variable Importance Analysis based on random Variable Combination (VIAVC) was used to select what features are present out of 224 features. Partial least squares discriminant analysis was performed leading to separation between pre-season and post-SRC groups. A Receiver Operator Curve (ROC) curve will be constructed to classify the features. Pathway topology analysis will also be completed to determine biological pathways are potentially affected following SRC.
Study Details
Timeline
Interventions
We aim to determine of a specific urine metabolomic biomarkers can diagnose concussion.