CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 50 enrolled
Drug / intervention
Tetracycline-Metronidazole (TM) group +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03656484
NCT03656484Phase 2Completed
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Innovative Technology for Assessing the Periodontal Disease and New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin

Concordia Dent Srl·interventional·Posted Sep 4, 2018·Updated Jan 27, 2020

In Brief

A Phase 2 clinical trial evaluating Tetracycline-Metronidazole (TM) group and TM-Melatonin-Hyaluronic acid (TM-MHa) group for Chronic Periodontitis. Completed, enrolled 50 participants across 2 sites.

Detailed Summary

The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the attachment level (AL) and alveolar bone support for moderate chronic periodontitis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Periodontitis
CountriesRomania
CollaboratorsCarol Davila University of Medicine and Pharmacy, Romanian National Authority for Scientific Research and Innovation (UEFISCIDI), University Politechnica of Bucharest, TURKEY MEDISEN Ltd

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedSep 4, 2018
Enrollment StartJan 15, 2019
Primary CompletionDec 20, 2019
TodayJul 2, 2026
Enrollment to primary: 11 monthsPosted 7.8 years ago

Interventions

Tetracycline-Metronidazole (TM) groupdrug

Following mechanical debridement (scaling and root planning) the above-mentioned paste will be topically administrated in the periodontal pocket of affected teeth once a day, for 30 consecutive days.

TM-Melatonin-Hyaluronic acid (TM-MHa) groupdrug

Following mechanical debridement (scaling and root planning) the above-mentioned paste will be topically administrated in the periodontal pocket of affected teeth once a day, for 30 consecutive days.