CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 2,860 enrolled
Drug / intervention
Low tidal Volume +3 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03657368
NCT03657368N/ACompleted
CompareCT.gov

Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project

The Cleveland Clinic·interventional·Posted Sep 5, 2018·Updated Aug 27, 2025

In Brief

A clinical study evaluating Low tidal Volume, High tidal Volume, and 2 other interventions for Orthopedic Surgery and Ventilation. Completed, enrolled 2,860 participants across 1 site.

Detailed Summary

The objective is to determine the optimal intraoperative ventilation strategy among the chosen tidal volume and positive end-expiratory pressure (PEEP) levels, and standardize it in an enhanced recovery pathway for orthopedic surgical patients. In particular, we propose to determine which combination of intraoperative tidal volume and positive end-expiratory pressure is best for patients having elective orthopedic surgery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOrthopedic Surgery, Ventilation
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedSep 5, 2018
Enrollment StartSep 3, 2018
Primary CompletionOct 23, 2020
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 7.8 years ago

Interventions

Low tidal Volumeprocedure

Tidal volume = 6 ml/kg predicted body weight

High tidal Volumeprocedure

Tidal volume = 10 ml/kg predicted body weight

Low PEEPprocedure

PEEP = 5 cm H2O

High PEEPprocedure

PEEP = 8 cm H2O