At a glance

ClinicalIndex Comparison Record

Phase 2Active· 30 target

Drug / intervention

Conjugated Estrogen +1 moredrug

Likely dose

Not stated in record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03663543

NCT03663543Phase 2ActiveOn TrackUpdated 2mo ago

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The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation

University of Pennsylvania·interventional·Posted Sep 10, 2018·Updated Apr 16, 2026

In Brief

A Phase 2 clinical trial evaluating Conjugated Estrogen and Normal saline for Ischemia Reperfusion Injury. Active but no longer recruiting, targeting 30 participants across 1 site.

Detailed Summary

Ischemia perfusion injury (IRI) is a major cause of organ injury during kidney transplantation. Currently there are no treatments for IRI other than dialysis. Preliminary studies in female mice have found protection from IRI when given short term estrogen supplements. This study will look at the effect of intravenous estrogen given peri-operatively to reduce the effect of IRI in female kidney transplant recipients.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsIschemia Reperfusion Injury

CountriesUnited States

Collaborators--

Timeline

Phase 2Active

20172018201920202021202220232024202520262027

Enrollment StartAug 2016

First PostedSep 2018

TodayJul 2026

Primary CompletionJan 2027

Study CompletionMay 2027

First PostedSep 10, 2018

Enrollment StartAug 26, 2016

Primary CompletionJan 31, 2027

Study CompletionMay 1, 2027

TodayJul 2, 2026

Enrollment to primary: 10.4 yearsPosted 7.8 years agoPrimary completion in 7 months

Interventions

Conjugated Estrogendrug

Dosing of conjugated estrogen will be given pre kidney transplant procedure and twice after reperfusion of the transplanted kidney.

Normal salinedrug

Dosing of normal saline will be given pre kidney transplant procedure and twice after reperfusion of the transplanted kidney.