At a glance
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The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial
In Brief
A Phase 4 clinical trial evaluating Isotonic crystalloids for Septic Shock. Completed, enrolled 1,554 participants across 31 sites in 8 countries.
Detailed Summary
The purpose of this trial is to assess patient important benefits and harms of IV fluid restriction vs. standard care fluid therapy in patients with septic shock.
Study Details
Timeline
Interventions
Types of fluid to be used in both intervention groups: * IV fluids given for circulatory impairment: Only isotonic crystalloids are to be used as per the Scandinavian guideline for fluid resuscitation * Fluids given to substitute overt loss: Isotonic crystalloids are to be used. If large amounts of ascites are tapped, then human albumin may be used * Fluids used for dehydration: Water or isotonic glucose should be used * Fluids used for electrolyte disturbances: Fluids should be chosen to substitute the specific deficiency, including water in the case of severe hypernatremia * Blood products are only to be used on specific indications including severe bleeding, severe anaemia and prophylactic in case of severe coagulopathy