At a glance
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Exercise Training Effects on Cognition and Brain Function in Multiple Sclerosis: A Systematically-Developed Randomized Controlled Trial
In Brief
A clinical study evaluating Treadmill Walking Exercise Training and Stretching-and-Toning Exercise Training for Multiple Sclerosis and Cognitive Impairment. Completed, enrolled 43 participants across 1 site.
Detailed Summary
Cognitive impairment is highly prevalent, poorly-managed, and disabling in persons with MS and exercise training might represent a promising approach to manage this symptom of the disease. The proposed study aims to examine the effects of 3-months of supervised, progressive (both intensity and duration) treadmill walking exercise training (designed based on pilot work and American College of Sports Medicine guidelines) compared with an active control condition (i.e., stretching-and-toning activities) on cognitive processing speed and functional MRI outcomes in 88 cognitively-impaired persons with MS. This study is critical for providing evidence supporting treadmill walking exercise training as a behavioral approach for managing slowed cognitive processing speed (i.e., the most common MS-related cognitive impairment) and improving brain health in persons with MS.
Study Details
Timeline
Interventions
12-weeks of supervised, progressive treadmill walking exercise training
12-weeks of supervised, progressive stretching-and-toning exercise training