CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 2,000 enrolled
Drug / intervention
Self-Guided Lifestyle Intervention +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03688126
NCT03688126N/ACompleted

U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk

Wake Forest University Health Sciences·interventional·Posted Sep 28, 2018·Updated Nov 3, 2025

In Brief

A clinical study evaluating Self-Guided Lifestyle Intervention and Structured Lifestyle Intervention for Alzheimer Disease. Completed, enrolled 2,000 participants across 6 sites.

Detailed Summary

The purpose of this research study is to see if lifestyle changes can protect memory and thinking (cognition) as we age. A recent study in Finland found that a combination of physical and cognitive exercise, diet, and social activity protected cognitive function in healthy older adults who were at increased risk of significant memory loss. So far no medications can rival this positive outcome. The point of POINTER is to test if lifestyle change can also protect against memory loss in Americans.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedSep 28, 2018
Enrollment StartJan 8, 2019
Primary CompletionMay 16, 2025
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 7.8 years ago

Interventions

Self-Guided Lifestyle Interventionbehavioral

Lifestyle intervention that involves providing participants with education, support, and tangible tools to assist them in developing and carrying out healthier lifestyle practices.

Structured Lifestyle Interventionbehavioral

Lifestyle intervention that involves a structured program of diet, physical and cognitive exercise, and management of cardiometabolic risks.