CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 66 enrolled
Drug / intervention
Cigarette +6 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03691350
NCT03691350Early Ph 1Completed
CompareCT.gov

The Effects of a Standardized Research E-Cigarette on the Human Lung: A Clinical Trial With Bronchoscopic Biomarkers

Ohio State University Comprehensive Cancer Center·interventional·Posted Oct 1, 2018·Updated Apr 23, 2026

In Brief

A Early Phase 1 clinical trial evaluating Bronchoscopy with Bronchoalveolar Lavage, Cigarette, and 4 other interventions for Cigarette Smoker and Current Every Day Smoker. Completed, enrolled 66 participants across 1 site.

Detailed Summary

This trial studies biomarkers obtained by bronchoscopy (bronchoalveolar lavage and lung brushings) to determine the effect of smoking e-cigarettes on the lungs. Studying samples of lung cells from participants who smoke e-cigarettes may help doctors learn more about changes that occur in deoxyribonucleic acid and identify biomarkers related to cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCigarette Smoker, Current Every Day Smoker
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

Early Ph 1CompletedFinished
20192020202120222023202420252026
First PostedOct 1, 2018
Enrollment StartSep 17, 2018
Primary CompletionOct 23, 2023
Study CompletionMar 10, 2024
TodayJul 2, 2026
Enrollment to primary: 5.1 yearsPosted 7.8 years ago

Interventions

Bronchoscopy with Bronchoalveolar Lavageprocedure

Undergo bronchoscopy with bronchoalveolar lavage

Cigarettedrug

Smoke usual brand

Electronic Cigaretteother

Smoke SREC with nicotine

Electronic Cigaretteother

Smoke SREC without nictoine

Laboratory Biomarker Analysisother

Correlative studies

Nicotine Replacementdrug

Receive NRT comprising patch, gum, or lozenge

Questionnaire Administrationother

Ancillary studies