CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 10 enrolled
Drug / intervention
Metoprolol +4 moredrug
Likely dose
Metoprolol 5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03696758
NCT03696758Phase 2Completed
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Improving Right Ventricular Function in Young Adults Born Preterm: A Pilot Study

University of Wisconsin, Madison·interventional·Posted Oct 5, 2018·Updated Mar 17, 2021

In Brief

A Phase 2 clinical trial evaluating Pulmonary Function Testing, Electrocardiogram, and 3 other interventions for Infant,Premature. Completed, enrolled 10 participants across 1 site.

Detailed Summary

The purpose of this research is to evaluate the short-term effects of sildenafil and metoprolol on heart function in young adults born premature.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsInfant,Premature
CountriesUnited States
CollaboratorsNational Center for Advancing Translational Sciences (NCATS)

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedOct 5, 2018
Enrollment StartOct 30, 2018
Primary CompletionFeb 24, 2020
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 7.7 years ago

Interventions

Pulmonary Function Testingprocedure

Subjects will undergo spirometry, Plethysmography, and diffusion capacity.

Electrocardiogramprocedure

Subjects will undergo an electrocardiogram to ensure sinus rhythm

Cardiac Magnetic Resonance Imagingprocedure

Subjects will undergo positron magnetic resonance imaging to detect images of the heart

Metoprololdrug

Subjects will receive intravenous metoprolol. Dose titrated 1-5 mg every 2 minutes to achieve goal heart rate of 55-65 beats per minute, or for subjects with a resting heart rate already at goal, titrated to achieve a 10-15% reduction in heart rate.

Sildenafildrug

Subjects will receive a 50 milligram tablet of sildenafil (to be taken orally)