CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 55,412 enrolled
Drug / intervention
Routine Care +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03697096
NCT03697096N/ACompleted
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INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection for Patients With Urinary Tract Infections (UTI)

Harvard Pilgrim Health Care·interventional·Posted Oct 5, 2018·Updated Jan 30, 2025

In Brief

A clinical study evaluating Routine Care and INSPIRE CPOE Smart Prompt for Urinary Tract Infection (UTI). Completed, enrolled 55,412 participants across 59 sites.

Detailed Summary

The INSPIRE-ASP UTI trial is a cluster-randomized controlled trial of HCA hospitals comparing routine empiric antibiotic stewardship practices with real-time precision medicine computerized physician order entry smart prompts providing the probability that a non-critically ill adult admitted with UTI is infected with a resistant pathogen. Note: that enrolled "subjects" represents 59 individual HCA hospitals that have been randomized.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsUrinary Tract Infection (UTI)
CountriesUnited States
CollaboratorsHospital Corporation of America, University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Centers for Disease Control and Prevention

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedOct 5, 2018
Enrollment StartOct 1, 2018
Primary CompletionMay 16, 2024
TodayJul 2, 2026
Enrollment to primary: 5.6 yearsPosted 7.7 years ago

Interventions

Routine Careother

Routine Antibiotic Stewardship Arm - Continuation of all antibiotic stewardship activities in accordance with national standards.

INSPIRE CPOE Smart Promptother

Quality improvement intervention: computerized physician order entry (CPOE) decision support alert that provides physicians with patient-specific risk estimate of having a UTI due to a multidrug resistant organism (MDRO) and recommends appropriate antibiotic choice for non-ICU patients in the first 3 days of hospitalization. Continuation of other antibiotic stewardship activities in accordance with national standards.