At a glance
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Randomized Trial of Endotracheal Tubes to Prevent Ventilator-Associated Pneumonia - PreVent 2 Study
In Brief
A Phase 2 clinical trial evaluating EVAC-PU-ETT and PVC-ETT for Ventilator-acquired Pneumonia. Completed, enrolled 1,074 participants across 1 site.
Detailed Summary
Researchers are looking at two different types of breathing tubes to see if one is better than the other at preventing pneumonia. One of the tubes has a design features to prevent leakage of fluids from the mouth and the back of the throat into the lower airways and lungs. This is important since leakage of small amounts of fluid into the lungs may lead to pneumonia. The other tube is the standard tube used at most hospitals. The hypothesis is that the use of a breathing tube that reduces fluid leakage into the lungs will reduce the risk of developing pneumonia and improve quality of life and cognitive function, compared to the standard tube. The study will also look at the safety of the modified breathing tube, compared to the standard tube.
Study Details
Timeline
Interventions
Placement of a EVAC-PU-ETT in the setting of emergent intubation.
Placement of a PVC-ETT in the setting of emergent intubation.