At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Comparison of Analgesic Efficacy of Ultrasound-guided Genicular Nerve Block Versus Saline Injection for Total Knee Replacement: a Prospective, Randomized Controlled Trial
In Brief
A Phase 4 clinical trial evaluating 15mL 0.25% bupivacaine, Genicular nerve block, and 1 other intervention for Post-operative Pain. Completed, enrolled 40 participants across 1 site.
Detailed Summary
This study seeks to examine the analgesic efficacy of genicular nerve blocks for pain after total knee replacement.
Study Details
Timeline
Interventions
Patients will be randomly assigned to either a genicular nerve block with bupivacaine or saline
The ultrasound-guided genicular nerve block will be performed at the site of the superior lateral, the superior medial, and the inferior medial genicular nerves. Color Doppler will be used to identify the arterial structures which serve as landmarks for the corresponding nerves. After skin local anesthetic infiltration, a 10 cm 21G insulated block needle will be inserted and aligned with the ultrasound scanning plane. Once satisfactory position of the needle is confirmed, 5mL of a solution containing 15 ml of 0.25% bupivacaine with 2mg dexamethasone or 5mL saline will be slowly injected. Spread of local anesthetic will be documented adjacent to the target nerve. This procedure will be performed at the site of the three genicular nerves described.
Patients will be randomly assigned to either a genicular nerve block with bupivacaine or saline