CI

At a glance

ClinicalIndex Comparison Record
Phase 3Active· 407 enrolled
Drug / intervention
Durvalumab +1 moredrug
Likely dose
Durvalumab 1500 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03706690
NCT03706690Phase 3Active

A Phase III, Randomised,Double-Blind,Placebo-Controlled,Study of Durvalumab as Consolidation Therapy in Patients With Locally Advanced,Unresectable NSCLC, Who Have Not Progressed Following Definitive, Platinum-Based Chemoradiation Therapy

AstraZeneca·interventional·Posted Oct 16, 2018·Updated May 13, 2026

In Brief

A Phase 3 clinical trial evaluating Durvalumab and Placebo for Carcinoma, Non-Small-Cell Lung. Active but no longer recruiting, targeting 407 participants across 87 sites in 10 countries.

Detailed Summary

This is a Phase III, randomised, double-blind, placebo-controlled, multicentre study assessing the efficacy and safety of durvalumab compared with placebo, as consolidation therapy in patients with locally advanced, unresectable, non-small cell lung cancer (Stage III), who have not progressed following definitive, platinum-based, chemoradiation therapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesChina, Hong Kong, India, Mexico, Philippines, Poland, Russia, South Korea, Taiwan, Turkey (Türkiye)
Collaborators--

Timeline

Phase 3Active
201920202021202220232024202520262027
First PostedOct 16, 2018
Enrollment StartNov 27, 2018
Primary CompletionJun 23, 2024
Study CompletionFeb 26, 2027
TodayJul 2, 2026
Enrollment to primary: 5.6 yearsPosted 7.7 years ago

Interventions

Durvalumabdrug

Durvalumab 1500 mg every 4 weeks \[q4w\] intravenously \[iv\] until clinical progression/ deterioration or confirmed radiological progression.

Placeboother

Matching placebo for infusion every 4 weeks iv until clinical progression/deterioration or confirmed radiological progression