CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 90 enrolled
Drug / intervention
Web-based CBT +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03707431
NCT03707431N/ACompleted
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A Randomized Trial of a Web-based Non-pharmacological Pain Intervention for Pediatric Chronic Pancreatitis

Seattle Children's Hospital·interventional·Posted Oct 16, 2018·Updated Apr 9, 2026

In Brief

A clinical study evaluating Web-based CBT and Pain Education for Chronic Pancreatitis and Acute Recurrent Pancreatitis. Completed, enrolled 90 participants across 1 site.

Detailed Summary

Abdominal pain is common in children with chronic and acute recurring pancreatitis (CP, ARP), and as they continue into adulthood, the disease progresses with increased pain and greater exposure to opioids. Despite the relevancy of early pain self-management for childhood pancreatitis, there have been no studies of non-pharmacological pain intervention in this population. The proposed project will evaluate a web-based cognitive behavioral pain management program delivered to a cohort of well-phenotyped children with CP/ARP and some community participants to reduce pain, pain-related disability and enhance HRQOL; it will also identify genetic risk factors and clinical and behavioral phenotypic factors associated with treatment response to enable precision medicine approaches.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Pancreatitis, Acute Recurrent Pancreatitis
CountriesUnited States
CollaboratorsUniversity of Iowa, University of Virginia, Washington University School of Medicine, M.D. Anderson Cancer Center, The University of Texas Health Science Center, Houston, Children's Hospital Medical Center, Cincinnati, Children's Hospital Los Angeles, Children's Hospital of Philadelphia, University of Toronto, McGill University Health Centre/Research Institute of the McGill University Health Centre, Medical College of Wisconsin, Massachusetts General Hospital, University of Minnesota, Ohio State University, University of Pittsburgh, University of California, San Francisco, University of Utah, Indiana University, Sydney Children's Hospitals Network, Cedars-Sinai Medical Center, Stanford University, Ariel Precision Medicine, University of Texas Southwestern Medical Center

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedOct 16, 2018
Enrollment StartApr 25, 2019
Primary CompletionJul 31, 2024
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 7.7 years ago

Interventions

Web-based CBTbehavioral

The eight child modules include: 1) education about chronic pain, 2) recognizing stress and negative emotions, 3) deep breathing and relaxation, 4) implementing coping skills at school, 5) cognitive skills (e.g., reducing negative thoughts), 6) lifestyle interventions, 7) staying active (e.g., pleasant activity scheduling), 8) relapse prevention. The eight parent modules are: 1) education about chronic pain, 2) recognizing stress and negative emotions, 3) operant strategies I (using attention and praise to increase coping), 4) operant strategies II (using rewards to increase positive coping and reach school goals), 5) modeling, 6) lifestyle, 7) communication, 8) relapse prevention.

Pain Educationbehavioral

The pain education website provides publicly available educational information about pancreatitis and abdominal pain. There is general information about pancreatitis from available web sources (e.g., National Pancreas Foundation) as well as information about chronic pain in childhood. The content does not include any instruction in the behavioral and cognitive skills taught within the WebMAP program.