CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 80 enrolled
Drug / intervention
thoracic epiduraldevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03719248
NCT03719248N/ACompleted
CompareCT.gov

High Thoracic Epidural Reduces Risks of Increased Left Ventricular Mass Index and Coronary Vascular Disease During Aortic Valve Replacement Alone or in Addition to Coronary Artery Bypass Graft Surgery

Ahmed Said Elgebaly,MD·interventional·Posted Oct 25, 2018·Updated Oct 25, 2018

In Brief

A clinical study evaluating thoracic epidural for Ischemia Coronary Artery Origin. Completed, enrolled 80 participants across 1 site.

Detailed Summary

Increased left ventricular mass index (LVMI) results from aortic valve lesions as an adaptive mechanism to help limit systolic wall stress and preserve ejection fraction (EF). This study Aim to investigate the effects of sympathetic blockade by HTEA on systolic and diastolic LV function in patients undergoing aortic valve replacement (AVR) alone or in addition to coronary artery bypass graft (CABG). It Designs as A prospective randomized controlled comparative study in which eighty patients received either general anesthesia ( control group n=40) or with high thoracic epidural analgesia(HTEA group n=40). Each group subdivided to normal (LVM) (n=20)or increased(LVM) group(n=20), all submitted to (AVR) alone or in addition to (CABG).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsIschemia Coronary Artery Origin
CountriesEgypt
CollaboratorsTanta University

Timeline

N/ACompletedFinished
2017201820192020202120222023202420252026
First PostedOct 25, 2018
Enrollment StartJan 1, 2017
Primary CompletionJan 1, 2018
TodayJul 2, 2026
Enrollment to primary: 1 yearPosted 7.7 years ago

Interventions

thoracic epiduraldevice

high thoracic epidural anesthesia (HTEA) combined with GA, transesophageal, transthoracic echocardiography and Holter ECG