At a glance
ClinicalIndex Comparison Record- ✓Physician-diagnosed chronic refractory cough lasting more than 8 weeks
- ✓Age 18 years or older
- ✓Must be cognitively impaired
- ✕Contraindications to MRI scanning, including metal implants or claustrophobia
- ✕Uncontrolled asthma or chronic respiratory disease other than refractory cough
- ✕Known allergic reaction to capsaicin (chilli)
- ✕Pregnancy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Functional Magnetic Resonance Imaging Study to Investigate ATP-sensitive Cough Neural Pathways in Patients With Chronic Cough Hypersensitivity
In Brief
A clinical study evaluating Adenosine Triphosphate, Capsaicin, and 1 other intervention for Cough. Completed, enrolled 58 participants across 1 site.
Detailed Summary
Persistent cough is a distressing symptom for people with respiratory disorders. Patients also often experience an ongoing urge-to-cough that prompts coughing, and which fails to resolve the sensation. Understanding how the brain controls cough and the urge-to-cough could lead to new cough suppressing therapies. The overall objective of this project is to use functional brain imaging (fMRI) to identify brain regions that are involved in the exaggerated urge-to-cough in humans with chronic cough. Our focus will be on the brainstem where information from the airways first arrives in the central nervous system.
Study Details
Timeline
Interventions
Participants will inhale escalating concentrations of Adenosine Triphosphate (ATP) to induce cough and the urge-to-cough
Participants will inhale escalating concentrations of capsaicin to induce cough and the urge-to-cough
Participants will have scans of their brain activity using 3 Tesla (3T) brainstem restricted functional brain imaging (fMRI)