CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 125 enrolled
Drug / intervention
Cipaglucosidase Alfa +3 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03729362
NCT03729362Phase 3Completed

A Phase 3 Double-blind Randomized Study to Assess the Efficacy and Safety of Intravenous ATB200 Co-administered With Oral AT2221 in Adult Subjects With Late-onset Pompe Disease Compared With Alglucosidase Alfa/Placebo

Amicus Therapeutics·interventional·Posted Nov 2, 2018·Updated Sep 11, 2025

In Brief

A Phase 3 clinical trial evaluating Cipaglucosidase Alfa, Miglustat, and 2 other interventions for Pompe Disease (Late-onset). Completed, enrolled 125 participants across 73 sites in 24 countries.

Detailed Summary

This is a phase 3 double-blind randomized study to study the efficacy and safety of intravenous ATB200 Co-administered with oral AT2221 in adult subjects with Late Onset Pompe Disease compared with Alglucosidase Alfa/placebo.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Australia, Austria, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Denmark, France, Germany, Greece, Hungary, Italy, Japan, Netherlands, New Zealand, Poland, Slovenia, South Korea, Spain, Sweden, Taiwan, United Kingdom, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20192020202120222023202420252026
First PostedNov 2, 2018
Enrollment StartDec 4, 2018
Primary CompletionDec 15, 2020
Study CompletionJan 15, 2021
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 7.7 years ago

Interventions

Cipaglucosidase Alfabiological

Participants received an intravenous (IV) infusion dose over a 4-hour duration every 2 weeks (Q2W).

Miglustatdrug

Participants received weight-based doses 1 hour prior to cipaglucosidase alfa infusion Q2W.

Alglucosidase Alfabiological

Participants received an IV infusion dose over a 4-hour duration Q2W.

Placebodrug

Miglustat matching placebo was administered orally 1 hour prior to alglucosidase alfa infusion Q2W.