CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 4,922 enrolled
Drug / intervention
Low-intensity monitoring strategy +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03734640
NCT03734640N/ACompleted

Optimal Post Tpa-Iv Monitoring in Ischemic Stroke

Craig Anderson·interventional·Posted Nov 8, 2018·Updated Mar 26, 2025

In Brief

A clinical study evaluating Low-intensity monitoring strategy and Guideline recommended standard monitoring for Acute Ischemic Stroke Patients Receiving Reperfusion Therapy. Completed, enrolled 4,922 participants across 54 sites in 7 countries.

Detailed Summary

OPTIMISTmain is an investigator-initiated and conducted, international, multicentre, stepped wedge cluster randomized controlled trial comparing the effects of different intensities of nursing care monitoring for patients with acute ischemic stroke of mild severity and without critical care needs after IV-tPA.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Chile, China, Malaysia, Mexico, United Kingdom, United States

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedNov 8, 2018
Enrollment StartApr 28, 2021
Primary CompletionDec 1, 2024
Study CompletionJan 23, 2025
TodayJul 2, 2026
Enrollment to primary: 3.6 yearsPosted 7.6 years ago

Interventions

Low-intensity monitoring strategyother

Post-tpa patients will be monitored in a lower intensity with less vital status and neurological assessment

Guideline recommended standard monitoringother

Post-tpa patients will be monitored in the usual care monitoring environment