CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 45 enrolled / 45 target
Drug / intervention
Transcranial electrostimulation (TES)device
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03735004
NCT03735004N/ACompletedOn Track (0.4/mo)Completion was 29mo ago

The Effects of Transcranial Electrostimulation (TES) on Postoperative Pain and Functional Patient Outcomes After Surgery for Obstructive Sleep Apnea Syndrome

Stanford University·interventional·Posted Nov 8, 2018·Updated Jun 22, 2026

In Brief

A clinical study evaluating Transcranial electrostimulation (TES) for Transcranial Electrical Stimulation. Completed, enrolled 45 participants across 1 site.

Detailed Summary

Postoperative pain after major surgery for obstructive sleep apnea (OSA), such as palatopharyngoplasty (PPP) and maxillomandibular advancement (MMA) is moderate-to-severe, and may persist for weeks. Control of this pain may be difficult, because OSA patients are very sensitive to traditional opioid pain medications, and their side effects. Poorly controlled pain slows down patients' recovery after surgery, including a return to normal daily activities and work, and may also delay wound healing. This study will investigate whether pain relief and recovery after surgery may be improved with the application of a weak electrical current to the skin of the patient's head (transcranial electrostimulation, TES). The TES works by blocking pain in the central nervous system through multiple mechanisms, which result in non-pharmacological pain relief, without drug-associated side effects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
201820192020202120222023202420252026
First PostedNov 8, 2018
Enrollment StartJul 18, 2017
Primary CompletionJan 11, 2024
Study CompletionFeb 9, 2024
TodayJul 2, 2026
Enrollment to primary: 6.5 yearsPosted 7.6 years ago

Arms & Interventions

TES 60 Hz DC:ACexperimental

Transcranial electrostimulation (TES) with combined direct (DC) and alternating (AC, 60 Hz) current

Device: Transcranial electrostimulation (TES)
TES 100 Hz DC:ACactive_comparator

Transcranial electrostimulation (TES) with combined direct (DC) and alternating (AC, 100 Hz) current

Device: Transcranial electrostimulation (TES)
TES with DC currentsham_comparator

Transcranial electrostimulation (TES) with direct current (DC) only

Device: Transcranial electrostimulation (TES)

Interventions

Transcranial electrostimulation (TES)device

Transcranial electrostimulation (TES) with combined direct (DC) and alternating (AC) current, or TES with DC only will be administered through the skin electrodes positioned on the patient's head