CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 19 enrolled
Drug / intervention
Porfimer Sodium +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03735095
NCT03735095Phase 2Completed
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Endobronchial Ultrasound Transbronchial Needle Guided Interstitial Photodynamic Therapy for Palliation of Locally Advanced Lung Cancer and Advanced Cancers Obstructing the Airway -Phase I/II

Roswell Park Cancer Institute·interventional·Posted Nov 8, 2018·Updated May 14, 2026

In Brief

A Phase 2 clinical trial evaluating Porfimer Sodium and Ultrasound-Guided Transbronchial Needle-Delivered Interstitial Photodynamic Therapy for Locally Advanced Lung Carcinoma and 7 related conditions. Completed, enrolled 19 participants across 1 site.

Detailed Summary

This Phase I/Il studies the side effects of endobronchial ultrasound guided interstitial photodynamic therapy work in treating patients with lung cancer that has spread to nearby tissues or lymph nodes. Photodynamic therapy consists of injecting a light sensitive drug called a photosensitizer, such as porfimer sodium, into the vein, waiting for it to accumulate in the tumor, and then activating it with a red laser light. Giving photodynamic therapy with Porfimer sodium may reduce the tumor size in patients with lung cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLocally Advanced Lung Carcinoma, Non-Small Cell Lung Carcinoma, Small Cell Lung Carcinoma, Stage III Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Stage IIIC Lung Cancer AJCC v8, Solid Tumor
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI), Pinnacle Biologics Inc., Simphotek Inc.

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedNov 8, 2018
Enrollment StartFeb 12, 2020
Primary CompletionJul 26, 2024
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 7.6 years ago

Interventions

Porfimer Sodiumdrug

Given IV

Ultrasound-Guided Transbronchial Needle-Delivered Interstitial Photodynamic Therapyprocedure

Undergo EBUS-TBN guided I-PDT