CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 454 enrolled
Drug / intervention
Smart-T + NRT +1 morecombination
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03740490
NCT03740490Phase 3Completed

Smartphone Based Smoking Cessation Intervention

University of Oklahoma·interventional·Posted Nov 14, 2018·Updated Aug 17, 2025

In Brief

A Phase 3 clinical trial evaluating Smart-T + NRT and QuitGuide + NRT for Smoking Cessation. Completed, enrolled 454 participants across 1 site.

Detailed Summary

Smoking is becoming increasingly concentrated among individuals with the lowest levels of income, education, and occupational status. In fact, smoking rates in the United States among people living below the poverty line is nearly twice as high as those above the poverty threshold. Highly flexible and low burden technology-based treatment approaches may overcome many of the barriers that have limited the use and effectiveness of traditional smoking cessation treatments among low socioeconomic status (SES) adults. Ecological momentary assessment (EMA), in which mobile devices are used to capture moment-to-moment experiences, allows for the measurement of phenomena in real-time within natural settings. Smartphone-based smoking cessation apps could offer easily accessible, highly tailored, and intensive interventions at a fraction of the cost of traditional smoking cessation counseling. The Smart-T app uses a lapse risk estimator to identify moments of heightened risk for lapse, and the algorithm tailors treatment messages in real-time based upon level of imminent smoking lapse risk and currently present lapse triggers. This study will compare smoking cessation rates for those randomized to the Smart-T app or the NCI QuitGuide app.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 3CompletedFinished
20192020202120222023202420252026
First PostedNov 14, 2018
Enrollment StartAug 26, 2019
Primary CompletionNov 17, 2023
TodayJul 2, 2026
Enrollment to primary: 4.2 yearsPosted 7.6 years ago

Interventions

Smart-T + NRTcombination

Smart-Treatment App and Nicotine Replacement Therapy

QuitGuide + NRTcombination

NCI QuitGuide Treatment App and Nicotine Replacement Therapy