CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 490 enrolled
Drug / intervention
Arfolitixorin +1 moredrug
Likely dose
Arfolitixorin 5 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03750786
NCT03750786Phase 3Completed

A Randomized, Multicenter, Parallel-group, Phase III Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer

Isofol Medical AB·interventional·Posted Nov 23, 2018·Updated Oct 26, 2023

In Brief

A Phase 3 clinical trial evaluating Arfolitixorin and Leucovorin for Colo-rectal Cancer. Completed, enrolled 490 participants across 94 sites in 10 countries.

Detailed Summary

This is a multicenter, randomized, parallel-group, Phase III study in at least 440 patients with advanced colorectal cancer to compare the efficacy of treatment with arfolitixorin versus Leucovorin in combination with 5-fluorouracil, oxaliplatin, and bevacizumab according to modified FOLFOX-6 until PD according to RECIST 1.1 criteria.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Austria, Canada, France, Germany, Greece, Japan, Spain, Sweden, United States
Collaborators--

Timeline

Phase 3CompletedFinished
20192020202120222023202420252026
First PostedNov 23, 2018
Enrollment StartDec 18, 2018
Primary CompletionNov 18, 2022
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 7.6 years ago

Interventions

Arfolitixorindrug

Bevacizumab 5 mg/kg intravenous infusion; Oxaliplatin 85 mg/m2 intravenous infusion; 5-FU 400 mg/m2 intravenous bolus; Arfolitixorin 60 mg/m2 intravenous bolus; 5-FU 2400 mg/m2 intravenous infusion; Arfolitixorin 60 mg/m2 intravenous bolus

Leucovorindrug

Bevacizumab 5 mg/kg intravenous infusion; Oxaliplatin 85 mg/m2 intravenous infusion; Leucovorin 400 mg/m2 intravenous infusion; 5-FU 400 mg/m2 intravenous infusion; 5-FU 2400 mg/m2 intravenous infusion