CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 26 enrolled
Drug / intervention
Moderately high oxalate/low calcium diet non-colonized +2 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03752684
NCT03752684N/ACompleted

Oxalobacter Formigenes Colonization and Oxalate Excretion in Healthy Adults

University of Alabama at Birmingham·interventional·Posted Nov 26, 2018·Updated Jan 30, 2026

In Brief

A clinical study evaluating Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, and 1 other intervention for Calcium Oxalate Urolithiasis. Completed, enrolled 26 participants across 1 site.

Detailed Summary

The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this influences the oxalate passed in urine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedNov 26, 2018
Enrollment StartApr 2, 2018
Primary CompletionApr 27, 2023
Study CompletionMay 22, 2025
TodayJul 2, 2026
Enrollment to primary: 5.1 yearsPosted 7.6 years ago

Interventions

Moderately high oxalate/low calcium diet non-colonizeddietary

Subjects will be instructed to ingest a controlled diet moderately high in oxalate before colonization

Oxalobacter formigenesdietary

Subjects will ingest live preparation of O. formigenes

Moderately high oxalate/low calcium diet colonizeddietary

Subjects will be instructed to ingest a controlled diet moderately high in oxalate after colonization