CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 116 enrolled
Drug / intervention
Combination therapy of vitamin C and thiamine +1 moredrug
Likely dose
Combination therapy of vitamin C and thiamine 50 mg/kgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03756220
NCT03756220Phase 2Completed
CompareCT.gov

Combination Therapy of Vitamin C and Thiamine for Septic Shock: Multi-center, Double-blinded, Randomized, Controlled Study

Tae Gun Shin·interventional·Posted Nov 28, 2018·Updated Oct 28, 2020

In Brief

A Phase 2 clinical trial evaluating Combination therapy of vitamin C and thiamine and Normal saline solution for Septic Shock and Sepsis. Completed, enrolled 116 participants across 6 sites.

Detailed Summary

The aim of this study is to evaluate the efficacy of early metabolic resuscitation with combination therapy using vitamin C and thiamine in improving organ function and survival in patients with septic shock.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSeptic Shock, Sepsis
CountriesSouth Korea
CollaboratorsNational Research Foundation of Korea

Timeline

Phase 2CompletedFinished
20192020202120222023202420252026
First PostedNov 28, 2018
Enrollment StartDec 1, 2018
Primary CompletionJan 13, 2020
Study CompletionApr 14, 2020
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 7.6 years ago

Interventions

Combination therapy of vitamin C and thiaminedrug

Vitamin C (50 mg/kg up to 3 g, every 12 hours) and thiamine (200 mg every 12 hours) intravenously administered mixed in 50 mL solution bags of normal saline for 2 days

Normal saline solutiondrug

Normal saline solution in a volume to match the treatment components administered mixed in 50 mL solution bags of normal saline for 2 days