CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 237 enrolled
Drug / intervention
Usual Care +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03756948
NCT03756948N/ACompleted
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Association Between Viscoelastic Tests-Guided Therapy With Synthetic Factor Concentrates And Allogenic Blood Transfusion In Liver Transplantation: A Before-After Study

Hospital Israelita Albert Einstein·interventional·Posted Nov 28, 2018·Updated Nov 28, 2018

In Brief

A clinical study evaluating Usual Care and Thromboelastometry-Guided Therapy with Synthetic Factor Concentrates for Liver Transplant; Complications and 2 related conditions. Completed, enrolled 237 participants.

Detailed Summary

BACKGROUND: Perioperative bleeding and transfusion are important causes of morbidity and mortality in patients undergoing liver transplantation. The aim of this study is to assess whether viscoelastic tests-guided therapy with the use of synthetic factor concentrates impact transfusion rates of hemocomponents in adult patients undergoing liver transplantation. METHODS: This is an interventional before-after comparative study. Patients undergoing liver transplantation before the implementation of a protocol using thromboelastometry and synthetic factor concentrates were compared to patients after the implementation. Primary outcome was transfusion of any hemocomponents. Secondary outcomes included: transfusion of red blood cells (RBC), fresh frozen plasma (FFP), cryoprecipitate or platelets, clinical complications, length of stay and in-hospital mortality.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLiver Transplant; Complications, Bleeding, Hemostatic Disorder
Countries--
Collaborators--

Timeline

N/ACompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedNov 28, 2018
Enrollment StartJan 1, 2007
Primary CompletionOct 30, 2015
Study CompletionJan 1, 2018
TodayJul 2, 2026
Enrollment to primary: 8.8 yearsPosted 7.6 years ago

Interventions

Usual Careother

Treatment of Coagulation Disorders Using Standard Coagulation Tests and Blood Components

Thromboelastometry-Guided Therapy with Synthetic Factor Concentratesother

Thromboelastometry-Guided Treatment of Coagulation Disorders Using Synthetic Factor Concentrates