CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 55 enrolled
Drug / intervention
Moderate-Intensity Aerobic Training +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT03760016
NCT03760016N/ACompleted
CompareCT.gov

Moderate-Intensity Exercise Versus High-Intensity Interval Training to Recover Walking Post-Stroke

University of Cincinnati·interventional·Posted Nov 30, 2018·Updated Mar 26, 2025

In Brief

A clinical study evaluating Moderate-Intensity Aerobic Training and High-Intensity Interval Training for Stroke. Completed, enrolled 55 participants across 3 sites.

Detailed Summary

The objective of this study is to determine the optimal training intensity and the minimum training duration needed to maximize immediate improvements in walking capacity in chronic stroke. A single-blind, phase II, 3-site randomized controlled trial has been planned. Fifty persons \>6 months post stroke will randomize to either moderate-intensity aerobic locomotor training or high-intensity interval locomotor training; each for 45 minutes, 3x/week for up to 36 total sessions over approximately 12 weeks. Clinical measures of walking function, aerobic fitness, daily walking activity and quality of life will be assessed at baseline (PRE) and after 4, 8 and 12 weeks of training (POST-4WK, POST-8WK, POST-12WK).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsStroke
CountriesUnited States
CollaboratorsUniversity of Delaware, University of Kansas Medical Center, Children's Hospital Medical Center, Cincinnati, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Timeline

N/ACompletedFinished
20192020202120222023202420252026
First PostedNov 30, 2018
Enrollment StartJan 4, 2019
Primary CompletionApr 25, 2022
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 7.6 years ago

Interventions

Moderate-Intensity Aerobic Trainingbehavioral

Overground and treadmill walking with speed continuously adjusted to maintain a target heart rate of 40 +/- 5% heart rate reserve, progressing up to 55 +/- 5% heart rate reserve.

High-Intensity Interval Trainingbehavioral

Overground and treadmill walking with 30 second bursts at maximum speed alternated with 30-60 second passive recovery periods. Intended to achieve a target average heart rate above 60% heart rate reserve.